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Printing pdfs with some inkjets (doesn't seem to affect laser printer) can eat up GBs of space with left over temp files.

I use Applejack from time to time and it seems the safest of any for removing caches.

A boot drive should have even more than the minimum free space of 15-20% - so with drives going for $100 - 125 for 200-300GB, disk space shouldn't really be a huge issue, though I do tend to keep ~/Library down to ~500MB and ~/ home folder is about 30GB.

In order to burn DVDs in iDVD you also want 24-32GB (unfragmented preferably) free space.