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Doesn't really matter what the devices are, AFAIK. If you go to the Show Clients display in the Sync preferences, and you see more than two clients, you'll encounter the problem. The only one I've knowingly encountered (with 3 Macs, 0 iPhones, and almost 8,000 entries in my data file) is that my data file continues to grow because right now the code that scrunches down the file apparently never thinks it is safe to do so. This is more of an issue if you have an iPhone in the mix. You can either use the CoalesceDatabase script posted elsewhere occasionally to do this process yourself, or stop syncing one of the Macs, which will get you down to 2 clients. Personally, I'd try running with 3 and running the script when the iPhone gets too slow.