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There have been a couple of threads over the last week from folks that have had this problem after installing the Safari 4 beta. It installs a new version of WebKit, which Mail then uses to display HTML mail. Unfortunately, that new version of WebKit breaks the AppleScript that our clipping service depends on.

We'll have a new release of OmniFocus with an updated clipping script before Safari 4 goes to a final release; for now, the fix is to revert to Safari 3.