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I'm having the same problem, and have reported it to Omni, but no reply yet.

For me, the problem started with Writeboards: I could edit the Writeboard text, but could not make a comment. Then I found that I couldn't make changes to any Backpack pages, or indeed any of 37signals' products. I am not sure, but I think this may have followed my upgrading to OmniWeb Beta 3 -- —ld it have introduced a new issue?

I have tried IDing as every possible browser, but nothing makes a difference: "501 - Not Implemented" every time.