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We do this in our business right now and while as policarpo says it is no where near supported it works just fine. We have three licenses used by three users sharing a mobileme account. We divide the work flow up by context. When I need to work on my tasks I simply select my contexts. You can have sub-contexts as well so if I need to work on phone calls I can select George:Calls and get to work.

We have been using Omnifocus for over a year in this way and have never had any corruption issues. That said of course always have a good backup.