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I use Postini, which I have to say is really good. You should really see if your upstream provider can enable it for you (it's generally out of the price range for anyone but an ISP or enterprise, I hear).

I have all the knobs "set to 11" and have it set to label my mail rather than quarantine it, so I can post-process it. Over the last six months I've had a 0% false positive and maybe 10 false negatives....for everyone in my domains!

I don't work there, never have, surely never will, own no shares etc...though I do know a couple of people who work there. Is that a connection?:)