At my workplace, we tie most of our progress together using Bugzilla. We use it not just to track bugs, but also to manage our new features (small ones anyway).

Using this rich source of tasks as inputs to a GTD system (OmniFocus) would absolutely make my day!

On the other hand, what about integrating the features of a bug-tracking system (automatic email notifications, discussions, types of bug closure, etc) into OmniFocus itself?