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Peter - syncing with mobile me is carried out via secure http - your password and all the data is encrypted in transit.

Once OmniFocus for Mac 1.5 and OmniFocus for iPhone 1.1 are both available, you'll be able to use the new Bonjour sync method we're adding. This will allow you to sync your data between your phone and your mac without using a third-party server.

(Of course, this means that your Mac and iPhone will both need to have access to the same wireless network to sync.)