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OmniFocus is my first step for gathering everything i need to do. I have two single-action folders (business and personal). Then i filter through my inbox and add activities with assign context to those folders. If the activity consist of series of task which takes more than couple of hrs or I need to rely on other resources (procurement) then I create Project folder and add milestones for that project as activities.
when i have projects and assign milestones within OmniFocus. I use iWork to plan my project and then use Omniplan to set schedule (including those milestones i have in omniFocus), resources, and cost and monitor the project using OmniPlan and iWork (numbers).