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You can do this by using Triggers in Quicksilver. You'll need to download Quicksilver from http://www.blacktree.com. Every mac user should install Quicksilver when they first get their computer. It's a great productivity tool. Don't think of it as another piece of software.

You can also use FastScripts http://www.red-sweater.com/fastscripts/index.html. I've never used it, but from what their web site describes, it should do what you want.

You can assign short cut keys through the System Preferences > Keyboard & Mouse > Keyboard Shortcuts screen. You can't assign short cut keys to AppleScript as far as I know. Only to applications.