Running: OmniGraffle/5.2/final-138.9 with Snow Leopard.

I am having the same issue. The actions to move to a different canvas work great using the 'browse tool', but when viewing the document in Presentation mode....I get very unexpected results. Either the buttons go to the wrong place or they just advance to the next canvas. I did play with all the presentation preference settings with no luck.

Again, once I bring it back to the 'browse' tool....it all magically works again.

I see that there is a 5.2.1 Beta. I looked at the release notes and it doesn't appear to address this issue so I haven't tried it out.

Thanks in advance.