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I look at the higher levels of GTD as not so much sources of actions, but sources of projects. I don't tick off actions like "Accomplish 1/1825th of 5 year plan to rule the galaxy", but instead generate smaller projects from my goals ("Take over block party"). Put the overall goals in OmniFocus as projects on hold, with review intervals set to some appropriate amount of time. Each time you look at them during the periodic review, you spin off some new projects, axe projects that are no longer seen as advancing your goals, etc. There's nothing that says you have to do this in OmniFocus; OmniFocus just gives you a handy mechanism for prodding you on schedule to do those reviews.