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Each resource can have its own work week, although the UI doesn't make this convenient to implement if by a different work week you mean one that is 8 or 9 time zones away from the rest of the crowd.

One problem that I've discovered while playing around with this is that tasks assigned to multiple resources will be scheduled as soon as one of the resources is available. Some of the time this is what you want (support ninjas, handle today's email), and some of the time (a meeting, for example) this won't do. I haven't found a way of marking a task to indicate that it can only be scheduled when all of the resources are available. You can schedule the task manually by setting constraints, but you don't get any help in figuring out when a good time would be.