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Well... I come to this as a form kGTD user and longtime practitioner of GTD so take my view with a grain of salt. I think OF is extremely usable and intuitive for someone who knows GTD. But if you don't know or only partially know GTD, it's probably a struggle.

A couple weeks ago I watched a demo of an app that downloads and organizes DNA info for certain types of reagents. Needless to say, I hadn't a clue how it worked or what it mean, but their users love it.

I think The Omni Group is right to focus on the GTD zealots for now, just as Apple focused on members of the Home Brew Computer Club before going to the larger market. There are many, many GTD practitioners out there who, if they love the product, will evangelize it to their friends.

Most every other GTD app I've seen to date is either incomplete, buggy (OUtlook plug-in) or a hack of one thing into another (kGTD). OF is a great leap forward from the status quo.