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I've got about 50 folders, 500 projects, 1100 todos, 50 contexts. I archive every month about 200 completed tasks.

Apart from OF2 beta all versions (Mac OS X, iPad, iPhone) cope with that amount no problem.

A bigger issue is to find the tasks you want to do in that quantity of tasks. You tend to get lost. OF does not have tags nor usable flags.

Nick