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Most of the time, it's fine to collapse the white space. In others, it can ruin a layout.

I have no problem with leaving the empty space (as OW does). For image-based ads, it's empty (white/clear). It's Flash ads and Iframe ads that leave the grey. If this bothers me, I just use CSS to set the element to display:none.

That being said, it would be nice if ALL blocked content in OW was treated like blocked images -- empty white space or the debossed "frame". I.E. no gray.