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Not currently. But I know there's an open request for it in Omni's feature database (because I asked for it a long time ago :-).

In the meantime, you could put your OmniFocus database on an encrypted disk image. But that may lead to issues with syncing. OmniFocus only syncs the database in the default location (~/Library/Application Support/OmniFocus/OmniFocus.ofocus). You might be able to rig up a soft link/alias type solution, but I haven't experimented with that myself and I suspect it's risky.

Another option is to turn on FileVault, which will simply encrypt your entire user account, including the default OmniFocus database.

Of course, if you're using syncing, neither of these solutions do anything for your data once it leaves your Mac.

-Dennis