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2.5 still seems pretty big to me. I don't have a whole lot of stuff. But when I don't sync for a while it gets up near 2G, I sync, and it gets back down to 160K when I run the coalesce script. I see a HUGE difference in sync times when my database is that small. I use mobile me also.

Do you have attachments pasted in? (may not be the right term) I've only been using OF since August, but still...2.5 sounds really, really big.