Yes, depending on what you're trying to do. We were doing rather extensive renovations of our flat and I used OmniGraffle for a couple of purposes. One was to floorplan the kitchen appliances, furniture and counter surfaces, but what I enjoyed most was using it to work out floor tiling. I'd taken pictures of the tiles in the store and used the images to figure out what pattern would look best in the space we had.

I wouldn't use it for any sort of architectural grade work, but it was quite fast for playing with ideas.