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I wouldn't say I ever turn my system "off," in fact, my system is what keeps me from having to worry about things while I'm trying to enjoy my free time. When something comes up while I'm at home, on vacation, etc, I'll enter a quick inbox item. I know it's been captured, so I don't have to think about it any more, and when I get back to the office, I'll process my inbox.

Having said that, one important notion that is highlighted in the GTD methodology is having multiple inboxes. It is recommended that you have the fewest number of inboxes that work for you, but for me, that is a minimum of 3 - OF, email, and voicemail. If I see an email or voicemail that does not require me to action it immediately, I'll leave it where it is. It's captured in it's own inbox, and I can incorporate these items into OF once I am back in business mode.