View Single Post
On the View menu there is an option to toggle guides. It doesn't have a keyboard shortcut by default but on MacOS you can assign keyboard shortcuts via System Prefs>Keyboard>Shortcuts.

You can also customise the toolbar that appears at the top of the window. Look for a button named Show/Hide Extras.

Also, if guides visibility are toggled off, a simple click anywhere in the canvas Rules will turn guides visibility back on.