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I can add to Omni's advantage the following:

- A lot more convenient nesting and rearrangement tools than Toodledo, all with keyboard shortcuts.

- Sync to iCal. I use that to either create events out of tasks (showing me busy for others, etc.) or to send readily arranged info to other programs (being the Mac standard, iCal can communicate with a lot of other software)

- Better integration with files/attachments/emails on your computer

- Integration with other Mac software through scripts

- As mentioned by others: A very vibrant, inspiring user forum and clever people making your Omnifocus even better with scripts you'll find in the forums.