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Interesting discussion on 43Folders about iGTD:

http://www.43folders.com/2007/04/08/igtd-quicksilver/

My favorite quote: "this ongoing Newton user has finally shifted the task management out of the Newton back to a laptop. iGTD is fabulous"

While it is a beta product and in development, it already has a decent backup system in place. I have to admit I'm really liking it, but I'll give TR 2 a look.