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I am having the same problem, and it looks that it finally slows down my mac (MacBook Pro, 2 Gb, 10.5.8) due to multiple pageins/pageouts. Today I had to quit Omnifocus to stop those, and I had 8 httpd processes. Omnifocus took a lot of time to quit, and, before quitting, it generated an error that I had emailed to Omni.
It could be that it is something else causing problems... but this has happened a few times since I bought and iPhone and started synchronizing it.