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The file used for iWeb is normally located in the library, like OmniFocus. If you move this file to a .Mac folder and you double-click on it, iWeb will open the file AND also remember this location the next time you open iWeb itself.

In this way the user file is automatically synced via .Mac adnd is it quit easy to work on more than one Mac on OmniFocus. Another pro is that it can be synced with a machine always online, being the iPhone webserver for OmniFocus.