I use a laptop @ work and a desktop @ home (and sometimes a 2nd laptop). I make extensive use of .Mac sync services to keep the machine as similar as possible. I even keep NetNewsWire sync'd via .Mac.

OmniFocus would be infinitely more useful for me (I've only had it for two days now and I can see how I won't be able to give it up) if I can keep the database sync'd between my various machines.

So, add my vote for .Mac syncing!