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Already sent this to the support ninjas, but thought I would post this here in case anyone else is experiencing this.

I upgraded to iOS 4.2 yesterday on my iPad and have noticed a significant drop in the performance of the OmniFocus for iPad app. Simply checking off an action as done can take several seconds for the checkmark to appear and then the item to disappear. Quite frustrating when I want to check off a bunch of items.

I have also noticed (and this was pre-iOS 4.2) that typing in the search is sluggish. I will bring up the search box and start typing and it will take several seconds for the first letter to appear. Once the first letter appears typing is smooth after that.