The Perspectives thing wont work for me for two reasons. 1. the iPhone app doesnt have perspectives and i use the iPhone app alot and 2. I really want total seperation of work and home stuff.
However, I have found a solution that works for me. I sync my home mac and my iPhone via MobileMe and I keep the database for my work stuff in my "DropBox" -
http://www.getdropbox.com/ This solution works for me because i dont need to see my work stuff on my iphone.
A bit of a hack but good enough untill OF lets you switch from one db to another (hint, hint)