[chriswitt]

What if you put a link to your OmniFocus.ofocus database file in your dock (at home and at work) and click that after you get your drive hooked up? Then you could be sure your using the same db file both at home and at work. You could even change the icon to look like the application.

Okay, I'm done giving out non-official advise. I'm sure someone more knowledgeable than me will jump in with help. ;-)