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Multiple desktops and iPhones sharing a single MobileMe account should be a supported configuration, provided that they are all expected to have the same data. I've been syncing with 3 desktops without any trouble (well, without any trouble that I wouldn't also have had with just 2 machines), and the sync code hasn't behaved in any fashion that would lead me to believe that it would break down with an additional client in the pool.

The MobileMe (or other WebDAV) server acts as the "neutral country" I mentioned, but perhaps a better characterization would be the "office gossip" -- it knows everyone's business, and tells it to any and all who ask :-) The OmniFocus.ofocus file (package, actually) there is handled in a fashion designed to allow essentially simultaneous reading and writing by multiple agents, whereas the local database is not.