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I have begun to investigate Ajax and will be looking at the possibility of turning my blog into an Ajax-run site, along the lines of a FileMaker database or an AppleScript application. I'm a pure beginner but it will be interesting nonetheless, and probably doable given that we now have the prototype.js library to do the dirty work for us ;-)

in any case, Ajax compatibility is a must. if that means compatibility with JSON (and I'm not sure what that is yet), then please make it so.