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Why do you want to be forced to use the cable? Bonjour sync works great in my experience, and I'm not sure how a hard-wired connection would improve it in any of the ways where it might be less than perfect. I spend most of my time being delighted that I can sync OmniFocus even when I've forgotten that pesky cable, unlike iTunes!

What specific deficiencies have you found that you hope might be improved upon?