I've found that looking at stuff in different ways back to back can be useful. By that, I mean cycling through a few key Perspectives, which I think you've already started to identify.
I'd highly recommend setting 'Next Review' dates (I set mine on the day of the week I do my weekly review), *and*, set Project 'Review every' cycles to something longer than '1 week' for things that don't require that short of an interval. Then you'll be able to focus more carefully on a shorter list of things every week. However, I'm in the same boat as you with those huge Single Action lists. I'm considering breaking those up, so that things that are approaching, but not quite, 'someday/maybe' status get reviewed every month or so. OTOH, too much process detail can get in the way. Curt Clifton has posted some really useful Perspective info in this forum.
http://forums.omnigroup.com/showthre...hlight=clifton
Back to cycling Perspectives: I process my Next Review Perspective until I'm caught up (during weekly review), then review a Due Soon Perspective, then a flagged Perspective. Still a work in progress, but what I have observed is that I feel much more confident I'm staying aware of stuff, and also that viewing information in different ways makes me think more. I.e., if you keep reviewing the same one Perspective, you can start to go numb seeing a long list of single actions in the same order over and over. Sometimes I'll key in some semi-random term in Search and see what comes up. It can be inspiring, and filters out other stuff momentarily.
Bob