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I just fired up OGP 4 on my late 2006 MacBook under SL, made 4 layers and about 60 objects and just played around for about 5 minutes. I'm not seeing any difference in the performance -- it still seems quite snappy.

What does Activity Monitor show going on with your computer? If OmniGraffle is hogging the CPU, getting some samples would probably be a good investigative step. Have you tried contacting the support ninjas at Omni?