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I'm an academic now, but I previously spent 6 years as an engineer and project manager doing large industrial installations. Some of those projects had similar complexity to building projects. (I also designed my own house and worked with a general contractor to build it, so have some sense of the relative scales.)

OmniFocus didn't exist at the time, but I wouldn't be inclined to use it for projects of that scale. I'd use something with industrial strength project management functionality, like OmniPlan. Even now where my largest project was to redesign and implement two large computing labs, I used OP to manage the timeline and dependencies. I just copied my personal tasks into OF. That was a bit redundant, but the Omni gurus are planning on my integration of OF and OP in the future. As far as I know they haven't indicated timing for that.
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Cheers,

Curt