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I use OmniFocus a lot, and I couldn't even recite to you the 10 Commandments of GTD! I just find it extremely helpful for organizing all my todos in a sane, easy manner.

Honestly I think it's easy to get up and running with OF, especially if you're not trying to follow the GTD religion. OO does not come close to the ease of use, and ease of mind, that OF provides for all my various to-dos.

(Caveat: I'm a very busy person with several different projects at the same time. For a less busy person OO might work fine.)