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This post helped me solve the same issue. After realizing I didn't have the firewall turned on I turned on the Firewall with "Allow only essential services" - I should have realized blocking incoming connections would block things like OmniFind sync.

Brian - right on the money about locking the door - it was easy enough to "set access for specific services & applications" and add the ones I know I trust - OmniFocus being one of them. I'm back in sync - thanks for the tip. I can't wait to try out the 1.5 update on the iPhone 3.0 update.