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If you are using the Quick Entry window, you can configure OmniFocus to save the item(s) and close the QE window when you press Return. See the General Preferences. In the main body of the program, pressing the Enter key instead of Return will close the current row without creating another. Depending on your keyboard, you might need to hold the fn key while pressing Return to get this function. Or you can hit the Esc key to end the edit.