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I've been syncing between 2 machines running Tiger on both plus Leopard on 1. The only problem I've noticed since the debut of the big batch of sync fixes that were the raison d'etre for iPhone OmniFocus 1.0.3 has been the problem Lizard reports about infrequent smooshing of the database. As I don't have an iPhone in the mix, that's not much of a problem at all.