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You don't mention the exact text of the error message you're getting, but we've had emails from a couple of folks that were getting the "OmniFocus has changed; do you want to let it access your keychain?" question over and over and over again. If that's what you're seeing, it turns out that's caused by a corrupt file on your machine; details on what to do about it are available in this Macworld article.

If that's not the problem you're having, let us know the exact text and we can try to lend a hand.