Thread: Parsing email?
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For what it's worth, once OmniFocus creates the rule in Mail, it seems you can edit it as you like. So, OF initially creates a rule to look for messages addressed to "xxx+omnifocus@mydomain.com". Then you can modify it (in Mail, not OF) to look for messages sent to "todo@mydomain.com".

My email provider does support plus-addressing, but I just didn't want to have to type "+omnifocus". It's faster for me to just send a note to "todo," and besides, "omnifocus" is not meaningful to me in the context of "just wanting to put an action on my list." I shouldn't have to think about OmniFocus at all until I get back to my main computer and start using it.