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I sync OmniFocus on my home and work Macs. I'm usually not at work on the weekends, and by late Sunday my OmniFocus file at home gets pretty big. That's solved every Monday when I get to the office and sync, but on Sundays I start seeing that cache message a lot.

Do you recommend that I stop syncing over the weekend and restart every Monday? This should solve the cache delays, but I'm not sure if repeatedly unsyncing and resyncing would cause problems.