[valvelifter]

It happens to me too, after starting up OF. I am convinced it's a Lion issue as it started happening only once I upgraded. Re-installing the app works for me as a temporary remedy, although I had my Mac database get corrupted once and luckily had a good copy on my server to restore. I sent Omni support a process sample a few weeks back, from the activity monitor when the app hung, I would recommend you sending in a process sample as well, the more info the better.