So, obviously, your first move should be to contact the Omni Group; while you're waiting for them to respond, you might want to try the following:
1. Create a new User on your machine
2. Log into the new user and launch OmniFocus to create the appropriate folders in the new Library
3. Quit OmniFocus (cross fingers)
4. Replace the new OmniFocus database in the new Library with a copy of your original database
5. Launch again and see if the issues persists
If the issue persists, it may be that your OF database is corrupted *or* the actual OS has some corruption. If it doesn't persist, then you probably have damaged OmniFocus support files in your original User; in this case, you would delete everything but the database, and then relaunch.
Note: a less drastic, less thorough step to take would be to make a backup of your OF support files (prefs, items in ~/Library/Application Support folder), remove these from your Library, and repeat steps 4 and 5 above, substituting 'current Library' for 'new Library'.
Last edited by sfkeydel; 2009-01-16 at 12:33 PM..
Reason: Added less drastic option