This is not so much an issue with color blindness as an issue with sites that opt for egregious, low-contrast color combinations like jalopnik (light green/beige text on grey background), use of horrific background images (think myspace) and use of non-standard link colors. Hence my preference for a universal override. Call me old-fashioned, but I have no patience for anything but sans-serif, black text on an appropriate high-contrast background (ref. David Siegel). I spend 8+ hours a day in front of a computer that eyestrain is a genuine concern. Unfortunately, I've yet to find an effective custom stylesheet override for OW which can substitute for a global setting. Safari's css override handling and Firefox's apprearance preferences behave as expected, while OW's do not. Having said that, I wouldn't even consider trading OW as my primary browser for either of these options.